I think your answer just got posted to the original Minify post, actually. See this comment by MrClay and this thread that he links to.

I’m going to reply to MrClay (he is the author of Minify) on that thread, so take a look over there. I’m running my mod with no Adsense problems, so I wouldn’t be surprised if it’s a PHP version/syntax issue.

original:

minified:

It would be so nice if WordPress had a real configuration/registry system, instead of the hodgepodge of using PHP global constants and writing serialized PHP into the database. (Thus there’s no way for arbitrary PHP code to just do Settings::getSetting(‘plugin_dir’) without initializing most or all of the tightly coupled WP application, at which point it’s already game over if you’re under any kind of load.) It is ridiculous that a plugin like WP Super Cache has to implement and maintain its own configuration system, all the way down to the filesystem level, just to be able to maintain state between requests. Even if WP just had a singleton registry class that you could plug into any kind of key-value backend (memcached, APC, filesystem), it would be so nice.

I guess WP is committed to staying PHP4 for the time being, though, and wonder if they would be doing more to make the core loosely coupled, extensible, OO and sane if that weren’t the case? WP devs have created the most beautiful weblog admin interface the world has ever seen and I suppose that’s where most of their love is directed … but I’m not a real blogger, I’m the systems side, so I don’t care about that, I just want to see the frontend page/template render get much, much faster, and that core is pretty much the same now as it was 5 years ago or even as b2.

At the then top-20 blog I worked for, I wrote a caching wrapper that was interchangeable between using a front-end reverse proxy (Squid, now Varnish), memcached or filesystem (via PEAR::Cache_Lite) for storage, along with a WP plugin to manage the expiry of the caches based on various events like post edits, comments etc. It was nice and would fail over (i.e. if Squid or memcached was unreachable, it would start using the filesystem). Of course it was all PHP5 — and this now 3 years ago.

/sigh